# SIGNATURE Applications

The SIGNATURE programs were developed by Jon Ison and colleagues at MRC HGMP for their protein domain research. They are included as an EMBASSY package as a work in progress.

### Applications in the current signature release

Program name | Description
--- | ---
libgen | Generate discriminating elements from alignments
matgen3d | Generate a 3D-1D scoring matrix from CCF files
rocon | Generate a hits file from comparing two DHF files
rocplot | Perform ROC analysis on hits files
siggen | Generate a sparse protein signature from an alignment
siggenlig | Generate ligand-binding signatures from a CON file
sigscan | Generate hits (DHF file) from a signature search
sigscanlig | Search ligand-signature library and writes hits (LHF file)